OBAGI Nu-Derm Blender — Prescription Hydroquinone 4%

Unlicensed medicine

Hydroquinone holds no UK marketing authorisation, so this product is supplied as an unlicensed medicine. This is standard for prescription hydroquinone in the UK. It does not mean the product is untested — hydroquinone is one of the most extensively studied depigmenting agents available — but it does mean your prescriber takes direct responsibility for the decision to prescribe it. Raise any questions with us before you begin.

What this product contains

4% hydroquinone, a prescription-only depigmenting agent. Supplied only following our online skin consultation and medical review, and prescribed for you individually. Do not share it with anyone else.

If you have also been prescribed Nu-Derm Clear, that contains 4% hydroquinone as well. Your total exposure across the two products is higher than from Blender alone, and the course limits below apply to the combination, not to each product separately.

Course length and breaks

Hydroquinone is prescribed in courses, not used continuously. Use for three to four months, then stop and take a break of the same length — three to four months — before starting another course. During the break, maintenance is with non-hydroquinone brightening agents such as vitamin C, azelaic acid or kojic acid, which hold your results without the risks that come with continuous use.

The break is not optional. Prolonged uninterrupted use carries a risk of exogenous ochronosis, a permanent grey-blue darkening of the treated skin, and the risk is higher in deeper skin tones. If you have seen no improvement after two months, stop and speak to your prescriber rather than continuing. A review is required before any repeat supply is issued.

Sun protection

Broad-spectrum SPF 50 every morning, without exception, and reapplied through the day if you are outdoors. Hydroquinone suppresses pigment production, but daylight reactivates it, including through windows and on overcast days. Without daily sun protection you will undo the treatment as you go. Avoid sunbeds entirely during your course.

Products not to combine

Benzoyl peroxide and hydrogen peroxide. Do not use these at the same time as hydroquinone. The combination causes temporary dark staining of the skin and can also stain fabrics and towels. It is harmless and reversible, but alarming if you are not expecting it. If you use a benzoyl peroxide acne product, tell us so we can separate them.

Other skin-lightening products. Do not use any other lightening or brightening prescription alongside this one.

Products to use with care

Tretinoin and other retinoids. Blender is frequently prescribed to be used with tretinoin, and that pairing is intentional and effective. It does increase irritation. Follow the schedule your prescriber gives you rather than starting everything at once, and if your skin becomes tight, red or flaky, contact us before stopping anything.

Exfoliating acids, scrubs and strong alcohol-based toners. Keep these to a minimum during your course.

Fragranced skincare. Your barrier is more permeable during treatment, which raises the risk of irritation and of developing a sensitivity. Keep the rest of your routine as bland as possible.

Who should not use it

Anyone pregnant, trying to conceive, or breastfeeding.

Anyone with a previous allergic reaction to hydroquinone or to any ingredient in the product.

This product contains sodium metabisulfite. Sulfite sensitivity can cause allergic reactions, including severe asthmatic episodes, in susceptible people. If you are asthmatic or know you react to sulphites, tell us before you begin.

This product contains a salicylate. If you have a known salicylate or aspirin sensitivity, tell us before you begin.

How to use it

Apply a thin layer to clean, completely dry skin across the whole face as directed, avoiding the eyelid area, and massage in until absorbed. Keep it away from the eyes, nostrils, lips and any broken or inflamed skin. Follow every morning application with SPF 50.

Avoid applying to large areas of the body at once.

What is normal

Mild stinging on application, and some redness, dryness or flaking in the first two weeks. This settles as your skin adjusts.

Stop and contact the clinic if

Stinging or burning persists rather than settling.

The skin swells, blisters, or develops a rash.

The treated area darkens, or develops a grey-blue or blue-black discolouration.

Any pigmentation appears to be worsening rather than improving.

Contact us on info@sebastianrose.co.uk or 0800 772 0137.

Storage

Store away from direct heat and sunlight with the cap closed. Hydroquinone oxidises on exposure to air and light. If the product turns dark brown, it has oxidised and should be discarded rather than used.

Other medicines and skincare

Tell your prescriber about every skincare product and medication you are using, including anything bought over the counter, before you start and if anything changes during your course.

Free UK delivery on orders over £99. Standard delivery 3–5 working days, £4.99; express next working day, £9.99. Add a cleanser or travel mini to reach free delivery.