Polynucleotide Hair Restoration

About this treatment

Plinest Hair Polynucleotide Treatment | Cardiff & South Wales Plinest Hair is a clinically proven injectable polynucleotide treatment derived from highly purified Italian trout DNA, developed by Mastelli using their patented HPT technology — the same laboratory behind our skin polynucleotide treatments. It represents one of the most significant advances in non-surgical hair restoration currently available in the UK. HOW IT WORKS Polynucleotides injected into the scalp stimulate fibroblasts, reduce the chronic inflammation that causes follicle miniaturisation, activate natural hair growth factors and support cellular regeneration of the follicle environment. Unlike PRP which relies on your own blood, Plinest Hair delivers a consistent, highly purified bioactive formula that repairs the biological conditions needed for healthy hair growth — reactivating dormant follicles and improving both hair density and quality progressively over time. WHAT THE EVIDENCE SAYS A 2025 clinical trial directly comparing Plinest Hair against PRP head-to-head found comparable efficacy — with all patients showing measurable improvement in hair density and quality, maintained at both 3 and 6 month follow-ups. A separate 2025 prospective study demonstrated significant improvement in both hair diameter and density from month one onwards. WHAT DOES IT TREAT? - Male and female androgenetic alopecia - Hormonal and stress-related hair thinning - Inflammation-driven follicle miniaturisation - Diffuse thinning across scalp, crown and parting - Post-partum hair loss - Patients seeking a blood-free alternative to PRP TREATMENT PROTOCOL → Phase 1: Weekly sessions for 4 weeks → Phase 2: Fortnightly sessions for 3 months → Maintenance: Every 6 months → Session duration: 30 minutes → Downtime: None — mild scalp redness for 24–48 hours Plinest Hair can be used as a powerful standalone treatment or combined with PRP for a comprehensive hair restoration protocol — your practitioner will advise the optimal programme at consultation. All treatments performed by qualified medical practitioners. Sebastian Rose — Cardiff, Swansea, Newport, Monmouthshire & South Wales.