POLYNUCLEOTIDES CARDIFF
DNA-BASED REGENERATION. CLINICALLY EVIDENCED. NATURALLY TRANSFORMATIVE.
POLYNUCLEOTIDES — DNA-BASED SKIN REGENERATION — BACKED BY OVER 90 CLINICAL STUDIES
Polynucleotides are one of the most rigorously evidenced treatments in aesthetic medicine — derived from highly purified salmon DNA and used in regenerative medicine since 1986. Unlike fillers or skin boosters that add volume or hydration temporarily, polynucleotides work at a cellular level, directly activating the fibroblast genes responsible for collagen synthesis, elastin production, and tissue repair. The result is progressive, natural improvement in skin quality, texture, tone, and firmness — using nothing but your body's own biology. No volume. No synthetic material. Pure regeneration.
15 min
From 199 British pounds
WHAT ARE POLYNUCLEOTIDES?
FOR LONG TERM SKIN REJUVENATION
What are polynucleotides?
Polynucleotides are not fillers and they are not skin boosters. They are a regenerative medicine treatment — one of the most clinically advanced injectables available in aesthetic medicine today, and one of the most misunderstood.
Where hyaluronic acid fillers add temporary volume and skin boosters hydrate the superficial dermis, polynucleotides work differently and more profoundly. They are composed of purified DNA fragments — extracted from salmon or trout DNA and processed to remove all allergenic proteins — which are injected into the skin where they interact directly with fibroblast cells. These DNA molecules activate the specific genes that control collagen synthesis, elastin production, and hyaluronic acid generation. Essentially, polynucleotides switch on your skin's own regenerative biology from within.
The result is gradual, progressive improvement in skin quality, firmness, tone, and texture that develops over weeks and months — and lasts 6-12 months with maintenance every six months.
Polynucleotides are backed by over 90 published clinical studies and 34 randomised controlled trials. They have been used in regenerative medicine since 1986.
At Sebastian Rose Medical Aesthetics Cardiff, we offer the most comprehensive polynucleotide programme in South Wales — using the world's leading formulations including Plinest, Plenhyage, Newest, Lumi Eyes, Rejuran, and Vitaran.
WHAT DO POLYNUCLEOTIDES TREAT?
Polynucleotides are among the most versatile injectables we offer. They can be used across the face, neck, décolletage, scalp, hands and body to address:
Skin quality and ageing
Fine lines and wrinkles, dull or dehydrated skin, loss of firmness and elasticity, crepey texture, and overall skin health and radiance.
Under-eye concerns
Dark circles, puffiness, hollowing, lax and thinning skin around the upper and lower eyelid, and fine periorbital lines. One of the safest and most effective treatments for this delicate area.
Acne scarring and pigmentation
Post-inflammatory marks, atrophic scarring, hyperpigmentation, uneven skin tone, and sun damage.
Hair loss
Androgenetic alopecia, diffuse thinning, scalp rejuvenation, and follicle stimulation.
Neck and décolletage
Horizontal neck lines, crepey skin, laxity, and sun damage.
Body
Inner arm and knee laxity, stretch marks, hand rejuvenation, and post-weight loss skin quality.
General facial regeneration
For patients wanting comprehensive, long-lasting improvement in skin health rather than a targeted volume-based treatment, a polynucleotide course delivers full-face cellular renewal in a completely natural, progressive way.
HOW DO POLYNUCLEOTIDES DIFFER FROM SKIN BOOSTERS?
POLYNUCLEOTIDES
How it works
Activates fibroblasts at a genetic level — stimulates your body to produce collagen, elastin and HA
Results appear
Gradually over 4-8 weeks
Longevity
6-12 months
Suitable for
Skin quality, regeneration, under-eyes, scarring, pigmentation, hair loss, crepey texture, anti-ageing
Reversible?
No
Clinically evidenced?
Yes — 90+ published studies, 34 randomised controlled trials
SKIN BOOSTERS
How it works
Attracts and retains moisture in the skin — provides instant hydration and superficial plumping
Results appear
Immediately, and over days to weeks
Longevity
3-6 months
Suitable for
Hydration, instant radiance, skin texture maintenance, mild skin quality improvement
Reversible?
Yes (hyaluronic acid dissolves naturally)
Clinically evidenced?
Yes. Evidence depends on the skin booster being used.
Many patients choose polynucleotides because they want improvement that looks as though it happened naturally over time — not an instant change. This is polynucleotides' greatest strength. They can also be combined with skin boosters , or even layered with Sculptra for both immediate glow and long-term regeneration — both of which are very popular protocols.
AM I SUITABLE FOR POLYNUCLEOTIDES?
You may be an ideal candidate for polynucleotide treatment if:
You want to improve overall skin quality, texture, tone, and firmness rather than add volume
You have under-eye concerns including dark circles, hollowing, fine lines, or thinning skin
You have acne scarring, post-inflammatory pigmentation, or skin damage you want to address
You are experiencing hair thinning or hair loss
You want a treatment that works with your body's own biology rather than adding synthetic material
You prefer gradual, natural improvement over an immediate dramatic change
You are in good general health with realistic expectations
You are prepared to commit to the recommended course of treatment (typically 3 sessions, 21 days apart)
WHO SHOULD NOT HAVE POLYNUCLEOTIDES?
Polynucleotide treatment may not be suitable if:
You are pregnant or breastfeeding
You are under the age of 18
You have active acne in the treatment area
You have haemophilia, a bleeding disorder, or are taking blood-thinning medications
You have an active infection of any type
You have been diagnosed with skin cancer
You have a history of keloid or hypertrophic scarring
You have active eczema, psoriasis, or dermatitis in the treatment area
You have certain autoimmune conditions — your practitioner will assess this at consultation
A thorough medical consultation is always carried out before any treatment at Sebastian Rose. We will always tell you honestly if polynucleotides are not right for you.
HOW DO POLYNUCLEOTIDES WORK?
Polynucleotide molecules are injected into the skin where they interact directly with fibroblast cells — the cells responsible for producing collagen, elastin, and hyaluronic acid. The DNA fragments activate specific fibroblast genes that control collagen synthesis, elastin production, and tissue repair. This is regeneration at a genetic level.
At the same time, polynucleotides stimulate angiogenesis — the formation of new blood vessels — improving oxygen and nutrient supply to the skin. They also inhibit melanogenesis (reducing pigmentation), provide potent anti-inflammatory and antioxidant protection, and induce accelerated cell turnover.
The process happens in stages:
Stage 1
Immediate (days 1–7)
The treatment area may feel slightly firmer and look mildly improved due to the initial inflammatory response triggering early fibroblast activity. Mild redness and small raised blebs are normal and resolve within hours to a couple of days.
Stage 2
Collagen Stimulation (weeks 2–6)
Fibroblast activation is underway. Skin begins to look more hydrated, calmer, and refined in texture. Under-eye area begins to improve.
Stage 3
Full Results (weeks 8–12 and beyond)
Significant improvement in skin quality, firmness, tone, and collagen density. Scarring and pigmentation visibly improving. Published studies demonstrate a 47% increase in collagen production and a 52% improvement in epidermal thickness within 23 days of treatment commencement.
WHAT DOES A POLYNUCLEOTIDE TREATMENT INVOLVE AT SEBASTIAN ROSE?
We will assess your skin, discuss your concerns and goals, and recommend the most appropriate polynucleotide formulation and protocol for you. We will never recommend a treatment that isn't right for your skin.
Your Treatment Plan
Most patients require a course of 3 sessions spaced an average of 3 weeks apart. Patients combining polynucleotides with skin boosters follow a 4-session protocol — 2 PN and 2 skin booster sessions, all 14 days apart. The right protocol for you is determined at consultation.
The Treatment
Sessions take 15–30 minutes depending on the areas treated. A topical numbing cream is applied for comfort. The polynucleotide solution is injected using a fine needle with a micro-papule or linear threading technique depending on the area and formulation. The treatment is well-tolerated and discomfort is minimal.
After Your Treatment
You may experience mild redness, small raised blebs, and a sense of warmth in the treated area immediately after treatment. These resolve within hours to a couple of days. Avoid touching the treated area, wearing makeup for at least one hour (ideally six hours), and avoid saunas, steam rooms, and intense exercise for 48 hours. Apply SPF 50 daily.
Follow-Up
We ask all polynucleotide patients to return approximately 20 days after each session so we can assess skin progress and ensure the protocol is on track.
POLYNUCLEOTIDE RESULTS — WHAT TO EXPECT
Unlike skin boosters, polynucleotide results develop gradually as your body produces new collagen and elastin. Here is a realistic timeline:
Days 1–3
Mild redness and small raised blebs at injection sites. These resolve quickly. Early fibroblast stimulation has begun.
Week 2–4
Skin begins to feel smoother and look more refined. Hydration and tone start to improve. Under-eye area begins to brighten.
Month 1–2
Visible improvement in skin quality, firmness, and texture. Fine lines reducing. Scarring and pigmentation improving. Collagen production actively increasing.
Month 2–3
Significant improvement visible. Skin quality, collagen density, and firmness at progressive peak. This is when patients typically notice the most marked difference.
Month 6–12
Results maintained. Maintenance treatments every 6 months recommended to sustain and build on results over time.
POLYNUCLEOTIDE FAQ'S
How long do polynucleotide results last?
Results typically last 6-12 months. We recommend maintenance sessions every 6 months to sustain and build on results over time. Duration varies depending on age, skin condition, lifestyle, and treatment area.
How many sessions will I need?
Most patients require 3 sessions spaced 20 days apart. Patients combining polynucleotides with skin boosters follow a 4-session protocol. This is determined individually at consultation.
Do polynucleotides hurt?
Topical numbing cream is applied before treatment. Most patients describe a mild pinching sensation. Treatment is very well-tolerated and discomfort is minimal.
Is there any downtime?
No significant downtime. Small raised blebs and mild redness resolve within hours to a couple of days. Most patients return to normal activities the same day.
When will I see results?
Results develop gradually over 4-12 weeks. Polynucleotides are not an immediate-result treatment — they work by stimulating your body to produce new tissue. The gradual improvement is what makes results look completely natural.
Can polynucleotides be combined with other treatments?
Yes — polynucleotides combine exceptionally well with skin boosters, Botox, dermal fillers, microneedling, Sculptra, PRP, Biofiller, and exosomes. At Sebastian Rose we often design bespoke combination protocols. Your practitioner will advise at consultation.
Are polynucleotides safe?
Polynucleotides have an excellent safety profile with no known serious side effects when correctly administered. They are backed by over 90 clinical studies. As with all injectables, temporary bruising, redness, and swelling may occur. All risks are discussed in full at consultation.
Are polynucleotides the same as PDRN?
PDRN (polydeoxyribonucleotide) is the specific DNA fraction used in polynucleotide treatments. The terms are often used interchangeably. All formulations we use are highly purified PDRN-based injectables. We offer both injectable polynucleotides. and in conjunction with microneedling, we prefer to use a PDRN formulation.
Can polynucleotides treat hair loss?
Yes. Polynucleotides are an effective treatment for androgenetic alopecia and diffuse hair thinning when injected into the scalp. They stimulate follicle activity and improve scalp tissue health. A course of 3-4 sessions is recommended.
Can men have polynucleotide treatment?
Absolutely. Polynucleotides are popular with male patients for skin quality improvement, anti-ageing, under-eye treatment, and hair loss. Results are subtle, progressive, and completely natural looking.
Do you offer polynucleotides for under-eyes?
Yes — Lumi Eyes (Nucleofill) is our specialist under-eye polynucleotide, specifically formulated for the delicate periorbital area. It improves dark circles, puffiness, fine lines, and thinning skin and is suitable for patients who are not candidates for tear trough filler.
Is there a fish allergy concern?
Polynucleotides are derived from salmon or trout DNA. If you have a known fish or seafood allergy, please inform us at consultation. Your suitability will be assessed individually before any treatment proceeds.
Intense skin hydration
Glow + Collagen in one
Advanced regeneration
60 ingredients
